Characterization of a Mycobacterium smegmatis mutant lacking penicillin binding protein 1.
نویسندگان
چکیده
The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of ponA in M. smegmatis resulted in a PBP1-deficient mutant that was sensitive to beta-lactam antibiotics, was more permeable to glycine, and grew slowly in liquid culture.
منابع مشابه
Purification and partial characterization of a penicillin-binding protein from Mycobacterium smegmatis.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 43 12 شماره
صفحات -
تاریخ انتشار 1999