Renin Proteinuria in the Rat

In the rat renin induces an intense but transient proteinuria, associated with the excretion of fibrinogen but not accompanied by any evidence of damage to the glomerulus. The inactivation of renin with respect to its pressor effect leads to a loss of its capacity to induce proteinuria. Angiotonin, when given in large amounts, induces proteinuria in the rat. It is concluded that this form of proteinuria is dependent on the pressor action of renin.