Meal ingestion markedly increases liver stiffness suggesting the need for liver stiffness determination in fasting conditions.

Effect of Meal Ingestion on Liver Stiffness in Patients with Cirrhosis and Portal Hypertension

BACKGROUND AND AIMS Liver stiffness is increasingly used in the non-invasive evaluation of chronic liver diseases. Liver stiffness correlates with hepatic venous pressure gradient (HVPG) in patients with cirrhosis and holds prognostic value in this population. Hence, accuracy in its measurement is needed. Several factors independent of fibrosis influence liver stiffness, but there is insufficie...

High risk of misinterpreting liver and spleen stiffness using 2D shear-wave and transient elastography after a moderate or high calorie meal

Food intake increases liver stiffness, but it is believed that liver stiffness returns to baseline two hours after a meal. The aim of this study was to investigate the impact of different sized meals on liver stiffness. Liver and spleen stiffness was measured with transient elastography (TE) and real-time 2-dimensional shear wave elastography (2D-SWE). Patients ingested a 625 kcal and a 1250 kc...

MR Elastography of Dynamic Postprandial Hepatic Stiffness Augmentation in Chronic Liver Disease

Introduction: Mesenteric blood flow increases markedly in response to the presence of food in the gut, with portal blood flow increasing up to 100% or more postprandially, compared with the fasting state (1). If the impedance to portal outflow remained constant, the increased flow would result in an increase in portal venous pressure. Yet, in normal humans, the portal venous pressure remains st...

Effects of Posprandial State and Mesenteric Blood flow on the Repeatability of Magnetic Resonance Elastography

Introduction: MR elastography (MRE) is a promising technique for non-invasive detection and assessment of liver fibrosis. Like any biomarker, its clinical utility will depend greatly on its repeatability (precision), which may be affected by physiological variability such as hepatic blood flow. It is well known that eating will dramatically increases splanchnic blood flow , and fasting status o...

Liver stiffness measurements increase after meal ingestion--an important step towards standardization.