Isozymic variability of Trypanosoma cruzi: biological and epidemiological significance.
نویسندگان
چکیده
M. TiBAYRENC', F. BRENIEREI, C. BARNABE2, J.-L. LEMESRE3, L. ECHALAR4 & P. DESJEUX5 'ORSTOM, IBBA, Embajada de Francia, Casilla 824, La Paz, Bolivia 2lBBA, Embajada de Francia, Casilla 824, l a Paz, Bolivia 3CISP, Institut Pasteur, 59019 Lille, France AUniversidad Mayor de San Andres, ISBA, Casilla 841, La Paz, Bolivia slnstitut Pasteur de Paris, ISBA, Embajada de Francia, Casilla 824, La Paz, Bolivia '
منابع مشابه
Epidemiology, biochemistry and evolution of Trypanosoma cruzi lineages based on ribosomal RNA sequences.
A puzzle in Chagas disease research has been to correlate molecular markers with epidemiology since isolates of Trypanosoma cruzi exhibit a broad host range, induce distinct clinical presentations in patients and show great diversity in biological and biochemical characteristics. Early studies on population genetics revealed substantial isozymic variability among isolates of T. cruzi defining t...
متن کاملEffects of some fractions from Achillea biebersteinii and A.millefolium on the epimastigotes of Trypanosoma cruzi
Higher plants are a potential source of new drugs to improve the treatment of Chagase disease, which is affecting 16-18 million people, with more than 100 million exposed to the risk of infection (Ambrozin et al., 2004; Coura & Castro, 2002). Current therapy is unsatisfactory, because the only two drugs available, benznidazole and nifortimox possess severe side effects and their activity is lim...
متن کاملAnalyses of 32 Loci Clarify Phylogenetic Relationships among Trypanosoma cruzi Lineages and Support a Single Hybridization prior to Human Contact
BACKGROUND The genetic diversity of Trypanosoma cruzi, the etiological agent of Chagas disease, has been traditionally divided in two major groups, T. cruzi I and II, corresponding to discrete typing units TcI and TcII-VI under a recently proposed nomenclature. The two major groups of T. cruzi seem to differ in important biological characteristics, and are thus thought to represent a natural di...
متن کاملEffects of some fractions from Achillea biebersteinii and A.millefolium on the epimastigotes of Trypanosoma cruzi
Higher plants are a potential source of new drugs to improve the treatment of Chagase disease, which is affecting 16-18 million people, with more than 100 million exposed to the risk of infection (Ambrozin et al., 2004; Coura & Castro, 2002). Current therapy is unsatisfactory, because the only two drugs available, benznidazole and nifortimox possess severe side effects and their activity is lim...
متن کاملFurther genetic characterization of the two Trypanosoma cruzi Berenice strains (Be-62 and Be-78) isolated from the first human case of Chagas disease (Chagas, 1909).
We describe here an extension of a previous genetic characterization of Trypanosoma cruzi strains (Be-62 and Be-78) isolated from the patient Berenice, the first human case of Chagas disease [Chagas, C., 1909. Nova Tripanomíase humana. Estudos sobre morfologia e o ciclo evolutivo do Schizotrypanum cruzi, n. gen., n. sp., agente etiolójico da nova entidade morbida do homem. Mem. Inst. Oswaldo Cr...
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ورودعنوان ژورنال:
- Annales de la Societe belge de medecine tropicale
دوره 65 Suppl 1 شماره
صفحات -
تاریخ انتشار 1985