The Antiinflammatory Sesquiterpene Lactone

Studies on the antiinflammatory, antipyretic and analgesic activities of santonin.

Santonin, a sesquiterpene lactone, commonly found in the plants of the family Compositae was found to show significant antiinflammatory activity on acute inflammatory processes. The activity profile of santonin closely resembled that of a standard non-steroidal antiinflammatory drug, diclofenac sodium. It also showed a significant inhibitory effect on granuloma formation; however, this effect o...

The Antiinflammatory Sesquiterpene Lactone Parthenolide Inhibits NF-kB by Targeting the IkB Kinase Complex

Novel Sesquiterpene Lactone and Sesquiterpene Lactone Glucoside from the Flowers of the Tunisian Pulicaria Laciniata (coss. Et Kral.) Thell

* corresponding author, e-mail : [email protected] Abstract: A sesquiterpene lactone 1 Lacinin and a sesquiterpene lactone glucoside 2 Laciniside, were isolated from the flowers of Pulicaria laciniata. Their structures were elucidated by extensive spectroscopic methods including 1D-( 1 H and 13 C) and 2D-NMR experiments, (CHcorr, HMBC, 1 H1 H COSY and NOESY) as well as high resolution E...

Anti-proliferative effect and apoptotic induction of sesquiterpene lactone parthenolide in a human breast cancer cell line

Parthenolide is a secondary metabolite, which naturally occurs in the feverfew plant and is responsible for its healing power. The potential of parthenolide in inhibition of cancer cell growth, alone or in combination with other anti-cancer therapeutics, have been studied in several laboratories. In this study, the effect of extracted parthenolide on the expression of seven pro-apoptotic genes,...

Sesquiterpene lactone glycosides from the roots of Ferula varia.

Seven new sesquiterpene lactone glycosides (1-7) were isolated from the H2O-soluble fraction from the MeOH extract of the roots of Ferula varia. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of compounds 1 and 2 were determined by modified Mosher's method.