A Sickle Cell Disease Carrier Family with a Pair of Dizygotic Twins from Kalahandi District of Western Orissa, India
نویسنده
چکیده
The sickle cell disease is a genetically inherited commonly encountered hematological disorder that causes high degree of morbidity, mortality and fetal wastage. The suspected cases of hemoglobinopathies suffering from anemia are routinely referred from different peripheral Primary Health Centres and Hospitals in the state of Orissa (India) to our Centre for detailed investigations and genetic/marriage counselling. Of these, a scheduled caste (Domb) family with twin children was referred from Kalahandi district of the state and was studied in detail. A carrier couple of sickle cell disease had born twin offspring with both carrier as well as the homozygous sickle cell disease. It is a rare occasion when a single pregnancy carries either two or more distinct abnormal genotypes at a time in a womb in human beings. Dizygotic twins are genetically different and provide appraisal of the expression of different genotypes under the same environment.
منابع مشابه
Genetic counselling in tribals in India
Genetic counselling in tribals unlike general population residing in cities and near villages is a difficult task due of their lower literacy and poor socio-economic status. However, sustained effort is essential with a close interaction in the local language, certain misbeliefs need to be removed gradually taking into account their socio-cultural background. The present communication deals wit...
متن کاملA monozygotic twin pair with β-thalassemia carrier status in a Dudh Kharia tribal family of Orissa
BACKGROUND The β-thalassemia syndrome is a genetically inherited commonly encountered hematological disorder in the state of Orissa. It causes high degree of morbidity, mortality and fetal wastage in the poor vulnerable people. AIMS AND OBJECTIVES There is an equal probability (50% chance) in every singleton pregnancy that a carrier parent of β-thalassemia major would either bear normal or ca...
متن کاملBirth control necessary to limit family size in tribal couples with aberrant heterosis of G-6-PD deficiency and sickle cell disorders in India: an urgency of creating awareness and imparting genetic counseling.
OBJECTIVES (i) To study the outcome of ignorance and lack of awareness about sickle cell disease and G-6-PD deficiency among Dhelki Kharia tribal families of Orissa, and (ii) to study the reproductive output in relation to clinical genetics and patho-physiological implications. METHODOLOGY A random genetic study of screening for hemoglobinopathies and G-6-PD deficiency among Dhelki Kharia tri...
متن کاملA Contribution To Medico- Ethnobotany of Kalahandi District, Orissa on Ear And Mouth Disease
Different herbal methods of treating ear and mouth disease in ethnomedicinal practice of the tribal people of Kalahandi district are described based on survey among scheduled caste and scheduled tribe population. 10 species have been found to be used as external application. All most all the species are found to be new Orissa on scrutiny of literature.
متن کاملAssessing clinical laboratory funding of Sickle Cell Disease and others associated Disorders in Khuzestan Province
Objective: The aim of this study was to assess clinical laboratory funding for differential diagnosis of sickle cell disease (SCD) and other associated disorders for better understanding of clinical types and prevention of sickling events. Material and Methods: This is a descriptive crossed-sectional study that analyzed the peripheral blood film, sickle cell preparation, hemoglobin electroph...
متن کامل