Sumoylation mediates divergent effects on transcription factors and can cause transcriptional repression or enhanced activation. Previously, we and others showed that PIAS proteins promote the sumoylation of STAT1 at Lys703, but the effect of the Lys703 mutation on
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چکیده
SUMO-1 conjugation selectively modulates STAT1-mediated gene responses Running title: Sumoylation modulates STAT1 responses Daniela Ungureanu1, Sari Vanhatupa1, Juha Grönholm1, Jorma J. Palvimo2 and Olli Silvennoinen1,3 1From Institute of Medical Technology, University of Tampere, Tampere, Finland; 3Department of Clinical Microbiology, Tampere University Hospital, Tampere, Finland; 2Department of Medical Biochemistry, University of Kuopio, Kuopio, Finland
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PIAS proteins promote SUMO-1 conjugation to STAT1.
Signal transducer and activator of transcription 1 (STAT1) is a critical mediator of interferon-gamma (IFN-gamma)-induced transcription that is regulated through posttranslational modifications and through transacting proteins such as protein inhibitor of activated STAT1 (PIAS1). PIAS proteins have been shown to function as E3-type small ubiquitin-like modifier (SUMO) ligases, and sumoylation h...
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Signal transducers and activators of transcription 1 (STAT1) is a critical mediator of interferon (IFN)-induced gene responses. Recently, STAT1 was found to become modified by small ubiquitin-like modifier 1 (SUMO-1) conjugation at Lys703 through the SUMO E3 ligase function of protein inhibitors of activated STAT (PIAS) proteins. However, the physiologic function of sumoylation in STAT1 is stil...
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