Genetical Genomics: Spotlight on QTL Hotspots
نویسندگان
چکیده
1 Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, Haren, The Netherlands, 2 Department of Human Genetics, Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 3 Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America, 4 School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America, 5 Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
منابع مشابه
Quantile-based permutation thresholds for QTL hotspot analysis: a tutorial
QTL hotspots, groups of traits co-mapping to the same genomic location, are a common feature of genetical genomics studies. Genomic locations associated with many traits are biologically interesting since they may harbor influential regulators. Nonetheless, non-genetic mechanisms, uncontrolled environmental factors and unmeasured variables are capable of inducing a strong correlation structure ...
متن کاملQuantile-Based Permutation Thresholds for Quantitative Trait Loci Hotspots
Quantitative trait loci (QTL) hotspots (genomic locations affecting many traits) are a common feature in genetical genomics studies and are biologically interesting since they may harbor critical regulators. Therefore, statistical procedures to assess the significance of hotspots are of key importance. One approach, randomly allocating observed QTL across the genomic locations separately by tra...
متن کاملGenetical Genomics Reveals Large Scale Genotype-By-Environment Interactions in Arabidopsis thaliana
One of the major goals of quantitative genetics is to unravel the complex interactions between molecular genetic factors and the environment. The effects of these genotype-by-environment interactions also affect and cause variation in gene expression. The regulatory loci responsible for this variation can be found by genetical genomics that involves the mapping of quantitative trait loci (QTLs)...
متن کاملTime‐course expression QTL‐atlas of the global transcriptional response of wheat to Fusarium graminearum
Fusarium head blight is a devastating disease of small grain cereals such as bread wheat (Triticum aestivum). The pathogen switches from a biotrophic to a nectrotrophic lifestyle in course of disease development forcing its host to adapt its defence strategies. Using a genetical genomics approach, we illustrate genome-wide reconfigurations of genetic control over transcript abundances between t...
متن کاملQuantile-based Permutation Thresholds for QTL Hotspots
QTL hotspots (genomic locations affecting many traits) are a common feature in genetical genomics studies, and are biologically interesting since they may harbor critical regulators. Therefore, statistical procedures to assess the significance of hotspots are of key importance. One approach, randomly allocating observed QTLs across the genomic locations separately by trait, implicitly assumes a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- PLoS Genetics
دوره 4 شماره
صفحات -
تاریخ انتشار 2008