Immunological Enhancement of Leukemia L1210 by Corynebacterium parvum in Allogeneic Mice1
نویسندگان
چکیده
We decided to investigate the immunological effects of C. parvum in an albogeneic murine tumor system. It was ex pected that C. parvum would have easily discernible adju vant effects that could be detected by in Vitro tests of cell mediated and humoral immunity. Instead, we found unex pectedly that at our dosage schedules C. parvum caused enhancement of tumor growth and a concomitant depres sion of several immunological parameters.
منابع مشابه
Immunological enhancement of leukemia L1210 by Corynebacterium parvum in allogeneic mice.
The effect of Corynebacterium parvum on the immune response of C57BL/6 mice (H-2b) to the allogeneic leukemia L1210 (H-2d) was investigated. Mice were either left untreated or given C. parvum i.v. or i.p. in various dosages. Seven days later they were challenged with 2.5 to 10 X 10(6) live L1210 cells i.p. Control animals almost always rejected the challenge. In contrast, most mice pretreated w...
متن کاملImmunotherapeutic response of concanavalin A-bound L1210 vaccine enhanced by a streptococcal immunopotentiator, OK-432.
Immunotherapeutic response to concanavalin A (Con A)-bound L1210 murine leukemic vaccine and immunopotentiators was examined in histocompatible animals bearing a small burden L1210 leukemic cells. When combined with Con A-bound vaccine, a streptococcal immunopotentiator, OK-432 (NSC B116209), prepared from Streptococcus pyogenes, was potent in antitumor therapy and resulted in a number of cured...
متن کاملDebatable edibles: bioengineered foods.
-We observed the growth of 2 sublines of leukaemia L1210 in histocompatible DBA2 mice given 103 cells i.p. and studied the protective effect of Corynebacterium parvum (CP). The growth of subline 1,1210 -M was unaffected by pretreatment with CP or admixture with 105 peritoneal cells (PC) from CP-treated mice. In contrast, the growth of subline L1210-C was inhibited; CP pretreatment increased the...
متن کاملEnhancement by Corynebacterium parvum of the normal and tumor tissue response to hyperthermia.
The effect of Corynebacterium parvum treatment on the response of tumor and normal tissue to hyperthermia (43.5 degrees) was studied. Animals were C3Hf/Sed mice from our defined flora mouse colony. The time at hyperthermia that achieved control of one-half of methylcholanthrene-induced fibrosarcomas and the foot reaction were examined after treatment. C. parvum, if given 3 to 32 days before hyp...
متن کاملThe adjuvant effect of Corynebacterium parvum: T-cell dependence of macrophage activation
Splenic and peritoneal macrophages from mice treated with Corynebacterium parvum enhanced the antibody response in vitro of normal nonadherent spleen cells to SRBC, but not to DNP-POL. This enhancement was dependent on the dose and time of administration of C. parvum and could be abrogated by pretreatment with carrageenan. Macrophages from T-cell-depleted mice failed to enhance the response, bu...
متن کامل