[An unusual suicide with dinitro-o-cresol].

Mechanism of Action of the Herbicide 4,6-Dinitro-o-cresol in Photosynthesis

The herbicide 4,6-dinitro-o-cresol inhibits electron transport to ferricyanide and non-cyclic photophosphorylation for 50% at about 15 /am. At higher concentrations the photosystem I depen­ dent M ehler reaction ascorbate/dichlorophenolindophenol to methyl viologen is stimulated, while cyclic photophosphorylation is inhibited. The herbicide thus is an inhibitory uncoupler. Although the chemical...

Some observations on the absorption and excretion of 4:6-dinitro-o-cresol. II. The elimination of 4:6-dinitro-o-cresol by man and by animals.

Harvey, Bidstrup & Bonnell (I951) have shown thaV 4:6-dinitro-o-cresol (DNOC) accumulates in man as the result of small daily doses and have shown that DNOC is very slowly eliminated from the body. This observation has received support from the evidence of a clinical case of a seriously poisoned spray operator reported by Pollard & Filbee (1951). A preliminary account of the work reported in th...

Suicide Substrates as Irreversible Inhibitors of Aavoenzymes

SUMMARY An increasing number of flavin dependent enzymes have recently been found to be inhibited by substrate analogs which fulfill the requirements set forth for suicide inhibitors. In most cases in-activation results from covalent modification of the flavin coenzyme; in other cases protein alkylation at the enzyme active center is involved. Examples of the first are the inactivation of gener...

Mycoplasma Pyrimidine Deoxynucleotide Biosynthesis Molecular Characterization of a New Family Flavin-Dependent Thymidylate Synthase

Purification and characterization of active-site components of the putative p-cresol methylhydroxylase membrane complex from Geobacter metallireducens.

p-Cresol methylhydroxylases (PCMH) from aerobic and facultatively anaerobic bacteria are soluble, periplasmic flavocytochromes that catalyze the first step in biological p-cresol degradation, the hydroxylation of the substrate with water. Recent results suggested that p-cresol degradation in the strictly anaerobic Geobacter metallireducens involves a tightly membrane-bound PCMH complex. In this...