Whole-Genome Sequencing and Comparative Analysis of Yersinia pestis, the Causative Agent of a Plague Outbreak in Northern Peru
نویسندگان
چکیده
The plague is a zoonotic disease caused by the bacterium Yersinia pestis. Here, we report the complete genome sequence of the Y. pestis strain INS, which was isolated from swollen lymph gland aspirate (bubo aspirate) of an infected patient from a pneumonic outbreak in 2010 in northern Peru.
منابع مشابه
The molecular detection of the causative agent of plague on the basis of the pla gene
Yersinia pestis, a gram-negative rod belonging to the Enterobacteriaceae family, is the causative agent of plague. Classical methods of detecting the organisms are time-consuming, expensive and dangerous. The aim of the study was to design a Real-time PCR assay on the basis of the pla gene of Yersinia pestis. In this research the Real- time PCR test was optimized by using special primers for ta...
متن کاملA Historical Report of Plague Outbreak in Northwestern Iran, 1966
Plague is an endemic disease to the west of Iran and has frequently stricken this area over the last decades. In 1954, Pasteur Institute of Iran established a research station in the west of the country and since then has monitored the plague outbreaks as well as the disease status in rodents and carnivores by dispatching research teams to different villages and localities. We noticed that ther...
متن کاملComparative scaffolding and gap filling of ancient bacterial genomes applied to two ancient Yersinia pestis genomes
Yersinia pestis is the causative agent of the bubonic plague, a disease responsible for several dramatic historical pandemics. Progress in ancient DNA (aDNA) sequencing rendered possible the sequencing of whole genomes of important human pathogens, including the ancient Y. pestis strains responsible for outbreaks of the bubonic plague in London in the 14th century and in Marseille in the 18th c...
متن کاملImproved assemblies and comparison of two ancient Yersinia pestis genomes
Yersinia pestis is the causative agent of the bubonic plague, a disease responsible for 9 several dramatic historical pandemics. Progress in ancient DNA (aDNA) sequencing rendered possible 10 the sequencing of whole genomes of important human pathogens, including the ancient Yersinia pestis 11 strains responsible for important outbreaks of the bubonic plague in London in the 14th century and 12...
متن کاملGenome Sequencing and Analysis of Yersina pestis KIM D27, an Avirulent Strain Exempt from Select Agent Regulation
Yersinia pestis is the causative agent of the plague. Y. pestis KIM 10+ strain was passaged and selected for loss of the 102 kb pgm locus, resulting in an attenuated strain, KIM D27. In this study, whole genome sequencing was performed on KIM D27 in order to identify any additional differences. Initial assemblies of 454 data were highly fragmented, and various bioinformatic tools detected betwe...
متن کامل