Genetics of sex determination in man and mouse.

نویسندگان

  • P N Goodfellow
  • S M Darling
چکیده

The cytological evidence has revealed a visible mechanical basis for the production of males and females in equal numbers and irrespective of external conditions (Wilson, 1909).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

I-17: The Mechanism of Gonadal Sex Determination

Background In mammals, a single exon gene SRY on the Y-chromosome is activated in the XY gonadal primordium and initiates a cascade of molecular and morphological events leading to testicular differentiation. SRY-encoded protein (SRY) is a transcription factor harboring a HMG-box DNAbinding motif that upregulates SOX9, which encodes another transcription factor sharing the DNA binding motif wit...

متن کامل

Mechanism of Sex Determination in Humans: Insights from Disorders of Sex Development.

In this review we will consider the gene mutations responsible for the non-syndromic forms of disorders of sex development (DSD) and how recent genetic findings are providing insights into the mechanism of sex determination. High-throughput sequencing technologies are having a major impact on our understanding of the genetic basis of rare human disorders, including DSD. The study of human DSD i...

متن کامل

I-43: Identification of SOX3 as an XX MaleSex Reversal Gene in Mice and Jumans

Background: Mammals utilise an XX/XY system of sex determination in which the Y-linked gene SRY (Sexdetermining region Y) exerts a dominant masculinising influence on sexual development. Sex chromosome homology and comparative sequence studies suggest that SRY evolved from the related SOX3 gene on the X chromosome, although there is no direct functional evidence to support this hypothesis. The ...

متن کامل

Characterising novel pathways in testis determination using mouse genetics.

Mammalian sex determination is the process by which the bipotential embryonic genital ridge commits to either the testicular or ovarian fate. The existence of a gonad primordium with 2 possible developmental outcomes, depending on the presence or absence of the Y chromosome, remains a fascinating paradigm for examining the manner in which genes cooperate to establish cell fate and regulate diff...

متن کامل

I-40: The Genetic Complexities of Human Sex-Determination

Background - MaterialsAndMethods N;Results N;Conclusion N;

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Development

دوره 102 2  شماره 

صفحات  -

تاریخ انتشار 1988