Investigating the mechanism of Mena-driven metastasis
نویسندگان
چکیده
منابع مشابه
Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.
UNLABELLED Fibronectin (FN) is a major component of the tumor microenvironment, but its role in promoting metastasis is incompletely understood. Here, we show that FN gradients elicit directional movement of breast cancer cells, in vitro and in vivo Haptotaxis on FN gradients requires direct interaction between α5β1 integrin and MENA, an actin regulator, and involves increases in focal complex ...
متن کاملThe Elephants in the Room: Sex, HIV, and LGBT Populations in MENA. Intersectionality in Lebanon; Comment on “Improving the Quality and Quantity of HIV Data in the Middle East and North Africa: Key Challenges and Ways Forward”
In response to this insightful editorial, we wish to provide commentary that seeks to highlight recent successes and illuminate the often unspoken hurdles at the intersections of culture, politics, and taboo. We focus on sexual transmission and draw examples from Lebanon, where the pursuit of data in quality and quantity is teaching us lessons about the way forward and where we are experiencing...
متن کاملPTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena
During breast cancer progression, alternative mRNA splicing produces functionally distinct isoforms of Mena, an actin regulator with roles in cell migration and metastasis. Aggressive tumor cell subpopulations express Mena(INV), which promotes tumor cell invasion by potentiating EGF responses. However, the mechanism by which this occurs is unknown. Here we report that Mena associates constituti...
متن کاملA Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.
The spread of cancer during metastatic disease requires that tumor cells subvert normal regulatory networks governing cell motility to invade surrounding tissues and migrate toward blood and lymphatic vessels. Enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) proteins regulate cell motility by controlling the geometry of assembling actin networks. Mena, an Ena/VASP protein, is upregula...
متن کاملThe effects of cytotoxic concentration of testosterone, progesterone and estradiol on anti-metastasis CD82/KAI1 expression level in brain glioblastoma cancer cells
Background: Studies have shown that sexual steroids can affect metastasis in cancer cells of nervous system at cellular and molecular level; however, the cellular and molecular mechanism of sexual steroids action on metastasis in cancer cells of nervous system is unclear in many cases. This study aimed at investigating the effects of cytotoxic dose of testosterone, progesterone and estradiol on...
متن کامل