Cinnarizine Orodispersible Tablets: a Chitosan Based Fast Mouth Dissolving Technology

In recent days the use of fast mouth dissolving tablets are well accepted by elderly, children and the patients having trouble in swallowing and even by the travelling patients who find it convenient to ingest. Cinnarizine is a piperazine derivative and is widely prescribed for the treatment of vestibular disorders and motion sickness. To enhance the anti-emetic and anti-migraine properties of Cinnarizine it is desirable to develop its fast acting dosage form hence a fast mouth dissolving tablet of Cinnarizine is always a better choice. Chitosan is the best known natural polysaccharide used for its versatile applications in pharmaceutical industry. Superdisintegrant property of chitosan has been utilized to develop a fast mouth dissolving tablet by utilizing a novel method of treatment which can replace any other superdisintegrant. The properties of the rapidly dispersible tablet, such as porosity, hardness, disintegration time, wetting time and dissolution time, were investigated accordingly and the formulation was optimized as per 3 level full factorial design and analysed for response surface methodology to decide the best formulation which further evaluated for in-vitro performances. Fast mouth dissolving or OroDispersible tablets (ODTs) of Cinnarizine with acceptable compression parameters and pleasant mouth feel could be prepared within the optimum region hence Cinnarizine OroDispersible tablets (CODT) can be prepared which upon administration disperse in mouth as soon as in contact with saliva and release the drug content immediately which can be absorbed directly through oral mucosa or can be swallowed without the aid of water hence provide faster and better therapeutic effects.