PI3K/Akt Pathway: A Role in d-Opioid Receptor–Mediated RGC Neuroprotection
نویسندگان
چکیده
Shahid Husain, Anis Ahmad, Sudha Singh, Carolyn Peterseim, Yasir Abdul, and Matthew J. Nutaitis Hewitt Laboratory of the Ola B. Williams Glaucoma Center, Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, United States Department of Radiation Oncology, University of Miami, Miami, Florida, United States Department of Physiology, Augusta University, Augusta, Georgia, United States
منابع مشابه
PI3K/Akt Pathway: A Role in δ-Opioid Receptor–Mediated RGC Neuroprotection
Purpose This study examines the role of PI3K/Akt pathway in δ-opioid receptor agonist (SNC-121)-induced RGC neuroprotection in a chronic glaucoma rat model. Methods Injecting hypertonic saline into the limbal veins of Brown Norway rats elevated IOP. Rats were treated either with 1 mg/kg SNC-121 or 3 mg/kg 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY-294002; PI3K/Akt inh...
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