One-pot synthesis of 1-alkyl-1H-indazoles from 1,1-dialkylhydrazones via aryne annulation.

نویسندگان

  • Nataliya A Markina
  • Anton V Dubrovskiy
  • Richard C Larock
چکیده

The reaction of readily accessible 1,1-dialkylhydrazones with commercially available o-(trimethylsilyl)aryl triflates provides a direct one-step route to pharmaceutically important 1-alkylindazoles. The products are obtained in high yields by one-pot NCS-chlorination/aryne annulation or Ac(2)O-acylation/deprotection/aromatization protocols.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 10 12  شماره 

صفحات  -

تاریخ انتشار 2012