Food for Thought ... Read-Across Approaches – Misconceptions, Promises and Challenges Ahead
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چکیده
Food for Thought ... Read-Across Approaches – Misconceptions, Promises and Challenges Ahead Grace Patlewicz , Nicholas Ball , Richard A. Becker , Ewan D. Booth , Mark T. D. Cronin , Dinant Kroese , David Steup , Ben van Ravenzwaay 8 and Thomas Hartung 9 1 DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA; 2 Toxicology & Environmental Research and Consulting (TERC), The Dow Chemical Company, Midland, MI, USA; 3 Regulatory and Technical Affairs Department, American Chemistry Council (ACC), Washington, DC, USA; 4 Syngenta Ltd, Jealott’s Hill International Research Centre, Bracknell, Berkshire, UK; 5 Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Liverpool, UK; 6 TNO, Zeist, The Netherlands; 7 Shell Oil Company, Shell Health Risk Science Team, Houston, TX, USA; 8 BASF Aktiengesellschaft, Experimental Toxicology and Ecology, Ludwigshafen, Germany; 9 Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, USA and University of Konstanz, CAAT-Europe, Germany
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Read-across approaches--misconceptions, promises and challenges ahead.
Read-across is a data gap filling technique used within category and analogue approaches. It has been utilized as an alternative approach to address information requirements under various past and present regulatory programs such as the OECD High Production Volume Programme as well as the EU's Registration, Evaluation, Authorisation and restriction of CHemicals (REACH) regulation. Although read...
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