The genetics of non-insulin-dependent diabetes mellitus.
نویسندگان
چکیده
NIDDM is one of the commonest metabolic disorders encountered in clinical practice, affecting an estimated 3% of the population of the Western World [1]. Prevalence data from Africa have recently been reviewed [2] and it appears that NIDDM has a prevalence in South Africa comparable to that found in developed countries, with a similar rate in rural and urban populations. In the northern part of South Africa, the available data indicates a low prevalence rate in both rural and urban populations in most areas studied [3]. However, in some countries, such as Tunisia, the prevalence in urban communities is similar to that of the Western World [4].
منابع مشابه
Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies
Objective(s): Diabetes mellitus (DM) is a major worldwide public health challenge, for which gene therapy offers a potential therapeutic approach. To date, no systematic review or meta-analysis has been published in this area, so we examined all relevant published studies on rodents to elucidate the overall effects of gene therapy on bodyweight, intraperitoneal glucose...
متن کاملHypercalciuria, Hyperphosphaturia and Growth Retardation in Children with Diabetes Mellitus
Background: Previous studies have demonstrated that patients with insulin-dependent diabetes mellitus (IDDM) have a high prevalence of osteopenia. Hypercalciuria has also been well documented in human diabetes and many children with insulin-dependent diabetes mellitus have short stature. Objective: To investigate the relationship of hypercalciuria and hyperphosphaturia with growth retardation ...
متن کاملDental damages in non-insulin dependent diabetes patients
Introduction: Changes in saliva and its biochemical content in diabetic patients can effect on supportive dental tissues and cause dental damage. Low carbohydrate diets, and good control of disease can reduce dental damage in diabetics. The aim of this study was to compare dental damage in patients with non-insulin dependent diabetes mellitus (NIDDM) patients and healthy individuals. Methods: ...
متن کاملInsulin effect on Leptin Concentration in Children with New Onset Insulin Dependent Diabetes Mellitus
Objective: Serum Leptin concentration reflects the body fat mass. There is controversial reports about the insulin effect on serum Leptin concentration. We wanted to examine the effect of insulin therapy on serum Leptin in children with new onset type I diabetes. Materials and Methods: This was a Cross-Sectional study in Children's Medical Center on 34 children who had new onset type I diabe...
متن کاملMolecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus.
Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. ...
متن کاملGenetics of insulin-dependent diabetes mellitus.
Recent studies that have focused on the detection of non-MHC susceptibility loci in insulin-dependent diabetes mellitus are reviewed. It has been confirmed that the region on human chromosome 11p contains such a susceptibility locus and recent research has attempted to identify the causative DNA variants and their functional role in disease.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Advances in genetics
دوره 32 شماره
صفحات -
تاریخ انتشار 1995