The antidepressant drug tianeptine blocks working memory errors: Pharmacological and endocrine manipulations of stress-induced amnesia in rats
نویسندگان
چکیده
vii Chapter One: Introduction 1 Hippocampus, Neuronal Atrophy and Memory 1 Stress, Corticosterone and Synaptic Plasticity 4 Current Stress and Working Memory Research 6 Tianeptine, Serotonin, NMDA and Memory 8 The Beta-Adrenergic System and Propranolol 9 Adrenalectomy and Memory 12 Current Experiments 16 Chapter Two: Experiment One: Tianeptine Blocks Stress-Induced Memory Errors on the Criterion-Based Multi-Day RAWM Working Memory 18 Task Method 18 Rats and Handling 18 Drug 19 Stress 19 Statistical Procedures 20 Results : Within Trials Analysis 20 Results: Retention Trials Analysis 21 Results: Plasma CORT Analysis for RAWM Criterion Testing 23 Chapter Three: Experiment Two: Tianeptine does not block Stress-Induced Memory Errors When Given After the Stressor on the Multi-day RAWM Task 24 Method 24 Rats and Handling 24 Drug 25 Stress 25 Statistical Procedures 26 Results: Within trials Analysis 26 Results: Retention Trial Analysis 27 Chapter Four: Experiment Three: Tianeptine Blocks Stress-Induced Memory Errors on the Novel One-Day Learning (ODL) Task 29 Method 29 Rats and Handling 29 Drug 30 ii Statistical Procedures 30 Results: Within Trials Analysis 30 Results: Retention Trials Analysis 32 Results: Plasma CORT Analysis for One-Day Learning Paradigm 33 Chapter Five: Experiment Four: Propranolol Does Not Block Stress-Induced Memory Errors on the One-Day Learning Task 35 Method 35 Rats and Handling 35 Drug 36 Statistical Procedures 36 Results: Within Trials Analysis: 5 mg/kg Propranolol Dose 37 Results: Retention Trial Analysis: 5 mg/kg Propranolol Dose 38 Results: Within Trials Analysis: 10 mg/kg Propranolol Dose 39 Results: Retention Trial Analysis: 10 mg/kg Propranolol Dose 41 Independent T-Test Analysis Between 5 and 10 mg/kg Propranolol Doses 41 Results: Plasma CORT Analysis for 5 mg/kg Propranolol Dose 41 Results: Plasma CORT Analysis for 10 mg/kg Propranolol Dose 41 Results: Independent T-Test Between Stress Groups 42 Chapter Six: Experiment Five: Adrenalectomy, Stress and Memory: Effects of Adrenal Steroids on Stress-Induced Memory Changes 44 Method 44 Rats and Handling Procedure 44 Adrenalectomy (ADX) Procedures 44 Corticosterone and Sodium Replacement Procedures 45 Behavioral Testing Regime 46 Blood Sampling and Preparation 46 Statistical Procedures 47 Results: Within Blocks Analysis 47 Results: Retention Trial Analysis 48 Results: Blood/CORT Analysis for ADX Experiments 50 Chapter Seven: Discussion Tianeptine Blocks Stress-Induced Memory Errors 52 Serotonergic Mechanism of Tianeptine Action 52 NMDA Receptor Mediated Mechanism of Tianeptine Action 53 Testing the Anti-Anxiety Properties of Tianeptine 54 Stress and Major Depressive Disorder (MDD): Pre-Clinical Applications of Tianeptine 56 Involvement of Corticosterone in the Formation and Blockade Of Stress Effects 57 The Role of Adrenal Hormones on Stress and Memory 60 Summary and Conclusions 61
منابع مشابه
Pre-training administration of tianeptine, but not propranolol, protects hippocampus-dependent memory from being impaired by predator stress.
Extensive research has shown that the antidepressant tianeptine blocks the adverse effects of chronic stress on hippocampal functioning. The current series of experiments extended this area of investigation by examining the influence of tianeptine on acute stress-induced impairments of spatial (hippocampus-dependent) memory. Tianeptine (10 mg/kg, ip) administered to adult male rats before, but ...
متن کاملTianeptine: An Antidepressant with Memory-Protective Properties
The development of effective pharmacotherapy for major depression is important because it is such a widespread and debilitating mental disorder. Here, we have reviewed preclinical and clinical studies on tianeptine, an atypical antidepressant which ameliorates the adverse effects of stress on brain and memory. In animal studies, tianeptine has been shown to prevent stress-induced morphological ...
متن کاملBeneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function
Tianeptine is a well-described antidepressant which has been shown to prevent stress from producing deleterious effects on brain structure and function. Preclinical studies have shown that tianeptine blocks stress-induced alterations of neuronal morphology and synaptic plasticity. Moreover, tianeptine prevents stress from impairing learning and memory, and, importantly, demonstrates memory-enha...
متن کاملEffects of co-administration of fluoxetine or tianeptine with metyrapone on immobility time and plasma corticosterone concentration in rats subjected to the forced swim test.
Major depression is frequently associated with hyperactivity of the hypothalamic-pituitary-adrenocortical axis, and glucocorticoid synthesis inhibitors have been shown to exert antidepressant action. The aim of the present study was to examine the effect of co-administration of fluoxetine or tianeptine with metyrapone on immobility time and plasma corticosterone concentration in male Wistar rat...
متن کاملEffect of cerebral administration of enalapril on spatial memory in scopolamine-induced amnesia in rats
Numerous studies conducted in laboratory animals and humans indicate that angiotensin converting enzyme inhibitors reinforce memory and learning. In this paper we study the effect of injection of enalapril into the cerebral ventricles on spatial memory of white mice in the double- y maze, following the induction of an Alzheimer- like amnestic model with scopolamine. To estimate the duration o...
متن کامل