3-Component Phase-Contrast MRI WSS Vectors in the Carotid Bifurcation are Concurrent with Local Atherosclerotic Plaque Risk Hypotheses
نویسندگان
چکیده
A. J. Barker, F. Zhang, P. E. Gates, L. A. Mazzaro, A. Stalder, J. Fulford, C. J. Lanning, M. Markl, and R. Shandas Diagnostic Radiology, Medical Physics, University Hospital Freiburg, Freiburg, Germany, Mechanical Engineering, University of Colorado, Boulder, CO, United States, Peninsula Medical School, University of Exeter, United Kingdom, Center for Bioengineering, University of Colorado at Denver Health Sciences, CO, United States, Division of Cardiology, The Children's Hospital, CO, United States
منابع مشابه
Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI.
A thorough understanding of the relationship between local hemodynamics and plaque progression has been hindered by an inability to prospectively monitor these factors in vivo in humans. In this study a novel approach for noninvasively reconstructing artery wall thickness and local hemodynamics at the human carotid bifurcation is presented. Three-dimensional (3D) models of the lumen and wall bo...
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BACKGROUND the purpose of this study was to analyze the in vivo distribution of absolute wall shear stress (WSS(abs)) and oscillatory shear index (OSI) in the carotid bifurcation and to evaluate its dependence on bifurcation geometry, the presence of internal carotid artery (ICA) stenosis, and recanalization therapy. METHODS AND RESULTS time-resolved 3D blood flow was acquired with flow-sensi...
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OBJECTIVE Atherosclerotic plaque development in the arterial wall is the result of complex interaction between the wall's endothelial layer and blood hemodynamics. However, the interaction between hemodynamic parameters and inflammation in plaque evolution is not yet fully understood. The aim of the present study was to investigate the relation between wall shear stress (WSS) and vessel wall in...
متن کامل4D MRI-based wall shear stress quantification in the carotid bifurcation: a validation study in volunteers using computational fluid dynamics
Background Remodeling of the vessel wall is associated with wall shear stress (WSS) magnitude (Malek, 1999). It has been suggested that local low or high WSS may respectively promote or prevent atherosclerotic lesions in the carotid vessel wall. The current procedure for WSS quantification is computational fluid dynamics (CFD), which is time-consuming and not always patient-specific. In the pas...
متن کاملThe influence of flow, vessel diameter, and non-newtonian blood viscosity on the wall shear stress in a carotid bifurcation model for unsteady flow.
OBJECTIVES The atherosclerotic process in arteries is correlated with the local wall shear stress (WSS). Plaque development particularly occurs in regions with recirculation (ie, where the WSS oscillates). We investigated the effects of non-Newtonian blood viscosity, variations in flow rate, and vessel diameter on wall phenomena in a carotid bifurcation model. MATERIALS AND METHODS The flow t...
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