The Oldest Recorded Case of Acromegaly and Gigantism in Iran.
نویسنده
چکیده
Here we commemorate the character and academic authority of Prof. Zabiholah Gorban (1903-2006), the founder of Shiraz medical school. No doubt, in the scope of history of contemporary medicine, he has been efficient and effective. With respect to this fact, his article on a rare case described in Acta anatomica published in Iran in 1966, entitled (Observations on a giant skeleton) is browsed and reviewed. A case named Siah Khan with combined acromegaly and gigantism that appears to have letters to say still after nearly half a century.
منابع مشابه
[Acromegaly--from myths to facts].
The authors present numerous historical descriptions of persons who might suffered from gigantism or acromegaly. The oldest medical data of patients, initial attempts of causal neurosurgical treatment, history of growth hormone, insulin-like growth factor-1, growth hormone releasing hormone and somatostatin discovery is reported. The highest contemporary living persons are also listed.
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The characteristic endocrine giant is a patient with an eosinophil adenoma of the anterior pituitary gland, the hypersecretion of growth hormone having been operative before union of the ephiphyses of the long bones and subsequently producing the added complication of acromegaly if the hypersecretion continues in late adolescence or adult life. In relatively minor degree both gigantism and acro...
متن کاملFamilial acromegaly - case study of two sisters with acromegaly.
In the majority of cases, acromegaly is sporadic. However, it can also occur in a familial setting as a component of MEN-1, MEN-4, Carney complex (CNC) or as the extremely rare syndrome of isolated familial somatotropinoma (IFS), the latter belonging to familial isolated pituitary adenomas (FIPA). The diagnosis of IFS is based on the recognition of acromegaly/gigantism in at least two family me...
متن کاملUnusual AIP mutation and phenocopy in the family of a young patient with acromegalic gigantism
Early-onset acromegaly causing gigantism is often associated with aryl-hydrocarbon-interacting receptor protein (AIP) mutation, especially if there is a positive family history. A15y male presented with tiredness and visual problems. He was 201 cm tall with a span of 217 cm. He had typical facial features of acromegaly, elevated IGF-1, secondary hypogonadism and a large macroadenoma. His patern...
متن کاملGigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.
BACKGROUND Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. METHODS We performed clinical and genetic studies of samples obtained from 43 patients with gigantism and then sequenced an implicated gene in samples from 248 patients with acromegaly. RESULTS We observed microduplic...
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ورودعنوان ژورنال:
- Archives of Iranian medicine
دوره 18 10 شماره
صفحات -
تاریخ انتشار 2015