Regulation of Nuclear Lamin Polymerization by Importin
نویسندگان
چکیده
REGULATION OF NUCLEAR LAMIN POLYMERIZATION BY IMPORTIN Adam, Stephen A., Kaushik Sengupta, and Robert D. Goldman From Department of Cell and Molecular Biology Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 1 These authors contributed equally to this work. Address correspondence to Stephen A. Adam, Ph.D., W129 303 E. Chicago Avenue, Chicago IL 60611 Fax: 312-503-7912; E-mail: [email protected]
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Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin beta.
Lamin B receptor (LBR), a chromatin and lamin binding protein in the inner nuclear membrane, has been proposed to play a vital role in nuclear envelope (NE) assembly. But the specific role for LBR in NE assembly remains unknown. In the present study, we show that overexpression of LBR causes membrane overproduction, inducing NE invagination and membrane stack formation, and that these processes...
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