The sample complexity of multi-reference alignment

. The growing role of data-driven approaches to scientific discovery has unveiled a large class of models that involve latent transformations with a rigid algebraic constraint. Among them, multi-reference alignment (MRA) is a simple model that captures fundamental aspects of the statistical and algorithmic challenges arising from this new paradigm. In this model, an unknown signal is subject to two types of corruption: a latent cyclic shift and the more traditional additive white noise. The goal is to recover the signal at a certain precision from independent samples. While at high signal-to-noise ratio (SNR), the number of observations needed to recover a generic signal is proportional 1/SNR, we show that it rises to 1/SNR in the more realistic low SNR regime. We propose an algorithm that achieves this optimal dependence on the SNR. Furthermore, we extend our results to cover heterogeneous MRA model where the samples come from a mixture of signals, as is often the case in applications such as Cryo-Electron Microscopy, where molecules may have different conformations. We provide the first known procedure that provably achieves signal recovery in the low SNR regime for heterogeneous MRA.