Aqueous humor turnover rates in the cat. I. Effect of acetazolamide.

Aqueous humor turnover in the cat eye determined by intracameral injection of inulin*C was found to be 2.1 per cent per minute, a value which is in close agreement with that reported for other species. The inhibition of aqueous humor formation induced by acetazolamide was dose dependent bid the quantities required were much higher than those reported necessary to lower the eye pressure. The data acquired in these experiments also alloived comparisons to be made between intraocular pressure and (1) anterior chamber volume; and (2) rate of aqueous humor formation. No statistically significant regression was found between the IOP and these two factors. In addition, an experimentally induced rise of IOP did not reflexly decrease the rate of aqueous humor turnover as has sometimes been suggested.