Induced susceptibility and resistance to an indigenous transplantable mouse tumor with autolyzed and alcohol-killed tumor tissue.

In a previous paper (3) describing experiments in which DBA/1 female mice and the transplantable dbrB adenocarcinoma indigenous to that strain were used, it was demonstrated that the inoculation of living tumor cells resulted in a sub stantial increase in resistance to subsequent tumor implants. Under certain conditions the technic em ployed rendered the animals completely refractory to secondary implants. Earlier unpublished experiments in our labora tory demonstrated that the subcutaneous inocu lation into mice of tumor tissue stored for 24 hours at 37.5° C. resulted in an increased growth of sub