LYMPHOID NEOPLASIA Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy
نویسندگان
چکیده
1Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, General Hospital, Southampton, United Kingdom; 2Cancer Research UK Experimental Cancer Medicine Centre, Cancer Sciences Division, Southampton University School of Medicine, General Hospital, Southampton, United Kingdom; and 3Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
منابع مشابه
Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy.
The anti-CD20 mAb rituximab is central to the treatment of B-cell malignancies, but resistance remains a significant problem. We recently reported that resistance could be explained, in part, by internalization of rituximab (type I anti-CD20) from the surface of certain B-cell malignancies, thus limiting engagement of natural effectors and increasing mAb consumption. Internalization of rituxima...
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