Maternal Diabetes Increases Small Conductance Ca -Activated K (SK) Currents That Alter Action Potential Properties and Excitability of Cardiac Motoneurons in the Nucleus Ambiguus
نویسندگان
چکیده
Min Lin, Qing-Hui Chen, Robert D. Wurster, Jeff T. Hatcher, Ye-Qi Liu, Lihua Li, Scott W. Harden, and Zixi (Jack) Cheng Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida; Exercise Science, Health and Physical Education Department, Michigan Technological University, Houghton, Michigan; Department of Physiology, Loyola University Medical Center, Maywood, Illinois; and Department of Pediatrics, The Research Institute for Children, Children’s Hospital, New Orleans, Louisiana
منابع مشابه
Maternal Diabetes Increases Small Conductance Ca Currents Which Alter Action Potential Properties and Excitability of Cardiac 2 Motoneurons in the Nucleus Ambiguus 3
27 Parasympathetic cardiac motoneurons (PCMNs) in the nucleus ambiguus (NA) 28 play a key role in regulating cardiac functions. In this study, we examine the effects of 29 maternal diabetes on excitability, action potential (AP) properties, and small 30 conductance Ca 2+-activated K + (SK) currents of PCMNs. Neonatal mice from diabetic 31 (OVE26 female, NMDM) and normal (FVB female, control) mo...
متن کاملMaternal diabetes increases small conductance Ca2+-activated K+ (SK) currents that alter action potential properties and excitability of cardiac motoneurons in the nucleus ambiguus.
Parasympathetic cardiac motoneurons (PCMNs) in the nucleus ambiguus (NA) play a key role in regulating cardiac functions. In this study, we examined the effects of maternal diabetes on excitability, action potential (AP) properties, and small conductance Ca(2+)-activated K(+) (SK) currents of PCMNs. Neonatal mice from diabetic (OVE26 female, NMDM) and normal (FVB female, control) mothers that h...
متن کاملMaternal diabetes increases large conductance Ca -activated K outward currents that alter action potential properties but do not contribute to attenuated excitability of parasympathetic cardiac motoneurons in the nucleus ambiguus of neonatal mice
Min Lin, Jeff T. Hatcher, Qing-Hui Chen, Robert D. Wurster, Lihua Li, and Zixi (Jack) Cheng Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida; Department of Exercise Science, Health and Physical Education, Michigan Technological University, Houghton, Michigan; and Department of Physiology, Loyola University M...
متن کاملSmall conductance Ca2+-activated K+ channels regulate firing properties and excitability in parasympathetic cardiac motoneurons in the nucleus ambiguus.
Small conductance Ca(2+)-activated K(+) channels (SK) regulate action potential (AP) firing properties and excitability in many central neurons. However, the functional roles of SK channels of parasympathetic cardiac motoneurons (PCMNs) in the nucleus ambiguus have not yet been well characterized. In this study, the tracer X-rhodamine-5 (and 6)-isothiocyanate (XRITC) was injected into the peric...
متن کاملCharacteristics of single large-conductance Ca2+-activated K+ channels and their regulation of action potentials and excitability in parasympathetic cardiac motoneurons in the nucleus ambiguus.
Large-conductance Ca2(+)-activated K+ channels (BK) regulate action potential (AP) properties and excitability in many central neurons. However, the properties and functional roles of BK channels in parasympathetic cardiac motoneurons (PCMNs) in the nucleus ambiguus (NA) have not yet been well characterized. In this study, the tracer X-rhodamine-5 (and 6)-isothiocyanate (XRITC) was injected int...
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