The response of transplanted chloroleukemia in the rat to treatment with antileukemic drugs.

I1E RECURRING QUESTION its (-alice!i-csearch regat-diing the applicatious of results obtaimsed with atsimal tumssors to the hunsuami problem-is ; the skepticismnn of such applications ofteus expressed by the investigators thennsselves ausd msot immfrequeuntly the aversious showus by sot-inc expeu-ts eungaged its cliurical oncology to data ol)taimred fronns expenimssemst-al caun(-er its amsinsals, bring iusto focus the useed to establish as completely as possible the sinurilanities as well as dissinnsilarities in ansatonsic characteristics aurd in chemurot-herapeutic rcspouse bet-weeus any experimental tumssor aund the amsabogous tunsor its nsiaun. The valuable imssmssediat-e ar-id loung-terns effect-s of tn-iethylemie thiophosphoramnside (Thio-TEPA) its the treatmusemut of a t-ramnsferahle (-hromllc mnsyelogemsous chioroleukensia in the rat has beets adequately documuseunted.’ The musethod of mnsaimstainiusg this leukensia by animnual traunsfer, its anatomisic characteristics, its peripheral blood picture, its tissue tusetastasis, aund the sinuilanity of these to the findings its chromsic myelogetnous leukemia its usuams have beet-i The purpose of the preset-it study, therefore, is usot to (-nitically e’s-aluate over boung periods the effects of various drugs omi this leukemruia, bust rather to devise a sisort terns screemnimug programsi its order to deternuimse whethemits respourse would parallel thatwhich is kusowus to occusr whets these drugs are used its (-ases of chronic nuyeloget-ious leukemnsia its musams.