Exacerbation of vasotonic angina pectoris by propranolol.
نویسندگان
چکیده
Using a double-blind protocol, we investigated the use of propranolol in patients with coronary artery spasm as assessed by subjective and objective variables. Both low-dose (40 mg every 6 hours) and high-dose (160 mg every 6 hours) propranolol were administered. At both doses, the duration of angina attacks was significantly prolonged but the frequency was not. We conclude that propranolol at doses up to 160 mg every 6 hours as single therapy is frequently detrimental in angina pectoris due to coronary artery spasm and should not be used as the sole treatment of this disorder.
منابع مشابه
Clinical, electrocardiographic, and haemodynamic effects of long-term use of propranolol in Prinzmetal's variant angina pectoris.
متن کامل
Effects of beta-adrenergic blockade (propranolol) on left ventricular hemodynamics and the electrocardiogram during exercise-induced angina pectoris.
متن کامل
Nadolol compared to propranolol for treating chronic stable angina pectoris.
In order to determine the relative efficacy and dose equivalency of propranolol four times a day and nadolol once daily for the treatment of stable angina pectoris, ten patients were studied in a double blind randomized placebo controlled crossover study. Total daily doses of propranolol and nadolol were determined by titrating until an equivalent degree of reduction in the heart rate response ...
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ورودعنوان ژورنال:
- Circulation
دوره 65 2 شماره
صفحات -
تاریخ انتشار 1982