A Biomimetic Strategy to Access the Silybins: Total Synthesis of (−)-Isosilybin A
نویسندگان
چکیده
We report the first asymmetric, total synthesis of (-)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible approach to this chalcone provides an entry to the preparation of the entire isomeric family of silybin natural products.
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