Serotonin-induced inhibition of KV current: a supporting role in pulmonary vasoconstriction?
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چکیده
Vasoconstriction? Current : A Supporting Role in Pulmonary V Serotonin-Induced Inhibition of K Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2006 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.0000219683.65556.74 2006;98:860-862 Circ Res. http://circres.ahajournals.org/content/98/7/860 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K+ channels.
The hypoxia-induced membrane depolarization and subsequent constriction of small resistance pulmonary arteries occurs, in part, via inhibition of vascular smooth muscle cell voltage-gated K+ (KV) channels open at the resting membrane potential. Pulmonary arterial smooth muscle cell KV channel expression, antibody-based dissection of the pulmonary arterial smooth muscle cell K+ current, and the ...
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متن کاملSerotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization.
Multiple lines of evidence indicate that serotonin (5-hydroxytryptamine [5-HT]) and voltage-gated K+ (KV) channels play a central role in the pathogenesis of pulmonary hypertension (PH). We hypothesized that 5-HT might modulate the activity of KV channels, therefore establishing a link between these pathogenetic factors in PH. Here, we studied the effects of 5-HT on KV channels present in rat p...
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Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. In this study, we investigated the effect of sustained hypoxic ventilation o...
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ورودعنوان ژورنال:
- Circulation research
دوره 98 7 شماره
صفحات -
تاریخ انتشار 2006