Quinacrine pellet nonsurgical female sterilization in Wonosobo, Indonesia.

OBJECTIVE To evaluate the efficacy, safety, and acceptability of two monthly transcervical applications of quinacrine, 252 mg, and ibuprofen, 55.5 mg, as pellets for sterilization. DESIGN Prospective clinical study. SETTING Family planning clinic of a referral hospital. PATIENT(S) Two hundred normal women who requested sterilization and volunteered for this method. INTERVENTION(S) Each woman received quinacrine, 252 mg, and ibuprofen, 55.5 mg, transcervically as pellets in the proliferative phase of two consecutive menstrual cycles from August 1992 to October 1993. MAIN OUTCOME MEASURE(S) Life-table pregnancy failure rates and incidence of complications and side effects. RESULT(S) The pregnancy failure rate was 2.0 per 100 women at 24 months. There were no serious complications, and side effects were transient. CONCLUSION(S) Intrauterine insertion of quinacrine pellets is a safe and acceptably effective method of nonsurgical female sterilization.