A Comparative Evaluation of 0.3% Eye Drops and in Situ Forming Gel of Pefloxacin Mesylate in Experimentally Induced Pseudomonas Conjunctivitis

The authors evaluated and compared the efficacies of eye drops and in situ forming gel of pefloxacin mesylate in pseudomonas induced conjunctivitis in 40 rabbits. The in-situ forming gel of pefloxacin mesylate was formulated as a liquid and when administered in the cul-de-sac, it gets converted to gel. The objective of the present research work was to demonstrate the in vivo activity of in situ gelling formulation and compared with marketed eye drops. No difference was obtained in all parameters of conjunctivitis on day 0, between in situ gelling formulation (Group I) and marketed eye drops (Group II), indicating that severity of conjunctivitis was similar initially between the two groups. Comparison of scores obtained with marketed eye drops and in situ gel formulation indicated that in situ gelling formulation was faster in relieving symptoms of conjunctivitis. The findings of the present study indicate that in situ forming gel of pefloxacin mesylate is a potential delivery system for the treatment of pseudomonas induced conjunctivitis.