Synthesis and Bioevaluation of 4-[(2/4-chloro-/2, 3-dichloro-/2/4-bromo-/2, 4-dinitro-/4-nitrophenyl) Anilinomethyl]-6-t-butyl-2H-1-benzopyran-2-ones
نویسندگان
چکیده
Synthesis of 4-[(2/4-chloro-/2,3-dichloro-/2/4-bromo-/2,4-dinitro-/4-nitrophenyl) anilinemethyl]6-t-butyl-2H-1-benzopyran-2-ones have been carried out. Synthesized compounds were characterized by 1HNMR, IR and other physical and analytical data. All of the synthesized compounds were evaluated for their antifungal activity against Aspergillus awamori and Sclerotium rolfsii and antibacterial activity against a bacterium of Bacillus species in vitro at 10, 50, 100 and 200 μg/ml concentrations. Compounds 4-[(2-chlorophenyl)anilinomethyl]-6-t-butyl-2H-1-benzopyran-2-one(11) and 4-[(4chlorophenyl) anilinomethyl]-6-t-butyl-2H-1-benzopyran-2-one(12) exhibited good antifungal activity among tested compounds. Compound 4-[(2-bromophenyl) anilinomethyl]-6-t-butyl-2H-1-benzopyran2-one(14) showed significant antibacterial activity against the test bacterium.
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