The life-span of complement-sensitive and -insensitive red cells in paroxysmal nocturnal hemoglobinuria.

Neutrophil life span in paroxysmal nocturnal hemoglobinuria.

We have studied neutrophil intravascular life span in six patients with paroxysmal nocturnal hemoglobinuria (PNH); four had normal neutrophil counts when studied and two were neutropenic. Five patients had enough circulating neutrophils to isolate for tests in vitro. Lysis of labeled neutrophils was greatly increased, compared to that of normal volunteers, when these neutrophils were incubated ...

Complement-sensitive red cells in aplastic anemia.

In view of the clinical association of aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH), the complement-dependent lysis of the youngest red cells of AA patients was studied. A complement-sensitive population of young red cells was found in five of six patients with AA. These cells were rapidly cleared from the circulation and were undetectable in the oldest cell fraction. Such...

Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. I. The sensitivity of PNH red cells to lysis by complement and specific antibody.

Life Span of Reticulocytes in Paroxysmal Nocturnal Hemoglobinuria.

P REVIOUS OBSERVATIONS have demonstrated the shortened life span of the red cell in patients with paroxysmal nocturnal hemoglohinuria ( PNH ).1.2 Studies of the survival of homologous PNH red cells by the Ashby technic and of autologous PNH cells labeled with radioactive sodium chromate have demonstrated a short and biphasic red cell survival curve in the patient and normal recipient. This life...

Paroxysmal nocturnal haemoglobinuria and diabetes mellitus.

Paroxysmal nocturnal haemoglobinura is an acquired disorder of the red cell membrane rendering the cell especially liable to lysis by activated complement. There may be a single or several clones of sensitive red cells and the disorder represents a defect at the pluripotential stem cell stage. This is supported by the findings of leucopenia and thrombocytopenia and the possible progression to p...