proton Magnetic resonance spectroscopy in Differential Diagnosis of brain tuMors

The aim of the investigation was to assess the informativity of proton magnetic resonance spectroscopy (PMRS) data in differentiation of brain tumors and nonneoplastic diseases with similar signal characteristics on standard MRI scans, as well as glioma grade determination. Materials and Methods. We examined 45 patients aged from 25 to 56 years with suspected expansive process of brain using proton magnetic resonance spectroscopy. The study was performed on MRI scanner “Magnetom Symphony 1.5 Т” (Siemens, Germany) using software package Spectroscopy Evaluation. The examination included routine brain investigations (MRI), as well as diffusion weighted images with diffusion factors of b=0, b=500, b=1000 with the following ADC-mapping. To receive graphic spectra and parametrical maps, there was used SE impulse sequence. To assess the grade of gliomas and metabolic changes in peritumoral area we studied peak height of choline, creatine, N-acetyl aspartate and their ratio. Results. According to histologically confirmed PMRS, 18 from 30 patients with cerebral gliomas were found to have low-grade gliomas (grade II), 12 patients — high-grade gliomas (grade III–IV). The results of the examination indicated high informative value of proton MR spectrometry as an important diagnostic technique in neuro-oncology. The modality is the most valuable and informative in the differentiation of cerebral gliomas, metastatic lesions, lymphomas, as well as in tumor grade determination of gliomas.