Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity
نویسندگان
چکیده
School of Medical Science, Griffith University, Southport 4222, Qld, Australia, Department of Chemistry, University of Otago, Dunedin 9016, New Zealand, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan 4111, Qld, Australia, Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 14220, Czech Republic, Department of Chemistry and Physics, Louisiana State University, Shreveport, LA, 71115 USA, Department of Biochemistry, National Institute of Cardiology, Mexico City 14080, Mexico, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech republic, Discipline of Pathology, Bosch Research Institute, Sydney Medical School, University of Sydney, Sydney 2006, NSW, Australia, Institute for Integrated and Intelligent Systems, and Institute for Glycomics, Griffith University, Southport 4222, Qld, Australia
منابع مشابه
Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II.
Mitochondrial complex II (CII) has been recently identified as a novel target for anti-cancer drugs. Mitochondrially targeted vitamin E succinate (MitoVES) is modified so that it is preferentially localized to mitochondria, greatly enhancing its pro-apoptotic and anti-cancer activity. Using genetically manipulated cells, MitoVES caused apoptosis and generation of reactive oxygen species (ROS) i...
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