Cladribine added to daunorubicin-cytarabine induction prolongs survival of FLT3-ITD+ normal karyotype AML patients.
نویسندگان
چکیده
Marta Libura, Sebastian Giebel, Beata Piatkowska-Jakubas, Marta Pawelczyk, Izabella Florek, Karolina Matiakowska, Bozena Jazwiec, Katarzyna Borg, Iwona Solarska, Magdalena Zawada, Sylwia Czekalska, Jolanta Libura, Malgorzata Jakobczyk, Karolina Karabin, Monika Paluszewska, Malgorzata Calbecka, Justyna Gajkowska-Kulik, Grazyna Gadomska, Marek Kielbinski, Anna Ejduk, Dariusz Kata, Sebastian Grosicki, Agnieszka Wierzbowska, Slawomira Kyrcz-Krzemien, Krzysztof Warzocha, Kazimierz Kuliczkowski, Aleksander Skotnicki, Jerzy Holowiecki, Wieslaw Wiktor Jedrzejczak,and Olga Haus
منابع مشابه
Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells.
Fetal liver tyrosine kinase 3 internal tandem duplication (FLT3 ITD) mutations are the most common molecular abnormality associated with adult acute myeloid leukemia (AML). To exploit this molecular target, a number of potent and specific FLT3 kinase inhibitors have been developed and are currently being tested in early phase clinical trials of patients with refractory AML. To explore the effic...
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Patients suffering from acute myeloid leukemias (AML) bearing FMS-like tyrosine kinase-3-internal tandem duplications (FLT3-ITD) have poor outcomes following cytarabine- and anthracyclin-based induction therapy. To a major part this is attributed to drug resistance of FLT3-ITD-positive leukemic cells. Against this background, we have devised an antibody array approach to identify proteins, whic...
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INTRODUCTION Internal tandem duplication of the FLT3 gene (FLT3/ITD) has been linked to poor outcome in acute myeloid leukemia (AML). However, the prognostic value of FLT3/ITD in various cytogenetic risk groups is still a matter of debate. The aim of this study was to evaluate the prognostic significance in patients with de novo AML and a normal karyotype or a t(15;17), t(8;21) or inv(16) (good...
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ورودعنوان ژورنال:
- Blood
دوره 127 3 شماره
صفحات -
تاریخ انتشار 2016