Silent cerebral infarcts and cerebral aneurysms are prevalent in adults with sickle cell anemia.
نویسندگان
چکیده
Vanderbilt-Meharry Sickle Cell Center for Excellence, Vanderbilt University Medical Center, Nashville, TN; Department of Radiology, Pediatric Radiology and Neuroradiology, Vanderbilt University Medical Center, Nashville, TN; Department of Radiology, Divisions of Emergency Radiology and Neuroradiology, Vanderbilt University Medical Center , Nashville, TN ; Rodeghier Consultants, Chicago, Illinois; Medicine, Drexel University College of Medicine, Philadelphia, PA; Department of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN
منابع مشابه
Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction.
Silent cerebral infarction is the commonest neurological abnormality in children with sickle cell anemia, affecting 30-40% 14 year olds. There are no known biomarkers to identify children with silent cerebral infarcts and the pathological basis is also unknown. We used an unbiased proteomic discovery approach to identify plasma proteins differing in concentration between children with and witho...
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Silent cerebral infarct (SCI) is the most common form of neurologic disease in children with sickle cell anemia (SCA). SCI is defined as abnormal magnetic resonance imaging (MRI) of the brain in the setting of a normal neurologic examination without a history or physical findings associated with an overt stroke. SCI occurs in 27% of this population before their sixth, and 37% by their 14th birt...
متن کاملLongitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease.
Children with sickle cell anemia (HbSS) are at high risk for neurologically overt cerebral infarcts associated with stroke and neurologically silent cerebral infarcts correlated with neuropsychometric deficit. We used complete magnetic resonance imaging (MRI) histories from 266 HbSS children, aged 6 through 19 years, who were enrolled in the Cooperative Study of Sickle Cell Disease (CSSCD) to e...
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ورودعنوان ژورنال:
- Blood
دوره 127 16 شماره
صفحات -
تاریخ انتشار 2016