Very high stereoselectivity in organocatalyzed desymmetrizing aldol reactions of 3-substituted cyclobutanones.
نویسندگان
چکیده
N-Phenylsulfonyl (S)-proline catalyzes the direct aldol reaction of 3-substituted cyclobutanones and aryl aldehydes in good yield and with excellent diastereoselectivity and enantioselectivity. This desymmetrization process provides highly functionalized cyclobutanones with control over three contiguous stereogenic centers.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 26 شماره
صفحات -
تاریخ انتشار 2012