Rhinovirus Induces Muc5ac in a Human Infection Model, & in Vitro via Nf-κb & Egfr Pathways
نویسندگان
چکیده
Christopher A. Hewson, Jennifer J. Haas, Nathan W. Bartlett, Simon D. Message, Vasile Laza-Stanca, Tatiana Kebadze, Gaetano Caramori, Jie Zhu, Mark R. Edbrooke, Luminita A. Stanciu, Onn M. Kon, Alberto Papi, Peter K. Jeffery, Michael R. Edwards and Sebastian L. Johnston. 1 Department of Respiratory Medicine, National Heart and Lung Institute, Centre for Respiratory Infection & MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, UK 2 Imperial College Healthcare NHS Trust, London, UK 3 Research Centre on Asthma and COPD, University of Ferrara, Ferrara, Italy 4 Department of Gene Therapy, National Heart and Lung Institute, Imperial College London at the Brompton Hospital, London, UK 5 Gene Interference, Functional Genomics, GlaxoSmithKline R&D, Stevenage, UK
منابع مشابه
Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways.
Rhinovirus (RV) infections are the major cause of asthma exacerbations, the major cause of morbidity and mortality in asthma. MUC5AC is the major mucin produced by bronchial epithelial cells. Whether RV infection upregulates MUC5AC in vivo is unknown and the molecular mechanisms involved are incompletely understood. We investigated RV induction of MUC5AC in vivo and in vitro to identify targets...
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