Scientific Category: Hemostasis, Thrombosis, and Vascular Biology A proangiogenic peptide derived from vascular endothelial growth factor receptor-1 acts through α5β1 integrin
نویسندگان
چکیده
*Both authors contributed equally. Dept. Biochemical Sciences "A. Rossi Fanelli", CNR Institute of Molecular Biology and Pathology, and Istituto Pasteur-Fondazione Cenci Bolognetti, University "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy Molecular and Cell Biology and Molecular Oncology Laboratory, IDI-IRCCS, via Monti di Creta 104, 00167 Rome, Italy Dept. Molecular Biology, University of Siena, via Aldo Moro 2, 53100 Siena, Italy Paul Scherrer Institut, Biomolecular Research, Molecular Cell Biology, 5232 Villigen-PSI, Switzerland
منابع مشابه
α5β1 integrin signaling mediates oxidized low-density lipoprotein-induced inflammation and early atherosclerosis.
OBJECTIVE Endothelial cell activation drives early atherosclerotic plaque formation. Both fibronectin deposition and accumulation of oxidized low-density lipoprotein (oxLDL) occur early during atherogenesis, and both are implicated in enhanced endothelial cell activation. However, interplay between these responses has not been established. The objective of our study was to determine whether end...
متن کاملCellular Biology Necl-5/Poliovirus Receptor Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis
Rationale: Vascular endothelial growth factor (VEGF), a major proangiogenic agent, exerts its proangiogenic action by binding to VEGF receptor 2 (VEGFR2), the activity of which is regulated by direct interactions with other cell surface proteins, including integrin ␣ V  3. However, how the interaction between VEGFR2 and integrin ␣ V  3 is regulated is not clear.
متن کاملMolecular mechanisms underlying the proangiogenic effect of factor XIII.
OBJECTIVE Coagulation Factor XIII (FXIII) was previously shown by us to induce angiogenesis. The aim of this study was to elucidate the molecular events underlying the proangiogenic effects of activated FXIII (FXIIIa) on human umbilical vein endothelial cells (HUVECs). METHODS AND RESULTS As shown by coimmunoprecipitation studies, FXIIIa crosslinked alpha(v)beta3 with vascular endothelial gro...
متن کاملPlasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-αVβ3 integrin cross talk.
OBJECTIVE Plasminogen activator inhibitor-1 (PAI-1) regulates angiogenesis via effects on extracellular matrix proteolysis and cell adhesion. However, no previous study has implicated PAI-1 in controlling vascular endothelial growth factor (VEGF) signaling. We tested the hypothesis that PAI-1 downregulates VEGF receptor-2 (VEGFR-2) activation by inhibiting a vitronectin-dependent cooperative bi...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Vascular endothelial growth factor–stimulated endothelial cells promote adhesion and activation of platelets
Coagulation abnormalities, including an increased platelet turnover, are frequently found in patients with cancer. Because platelets secrete angiogenic factors on activation, this study tested the hypothesis that platelets contribute to angiogenesis. Stimulation with vascular endothelial growth factor (VEGF, 25 ng/mL) of human umbilical vein endothelial cells (HUVECs) promoted adhesion of nonac...
متن کامل