Reaction of alkylating mutagens and carcinogens with nucleic acids: detection and estimation of a small extent of methylation at O-6 of guanine in DNA by methyl methanesulphonate in vitro.

the same. Only a small amount of non-metabolized EPTC remained. With only minor differences in the EPTC metabolism patterns of the anhydride-treated and non-treated corn, it would be difficult to explain the anhydride's action on the basis of EPTC metabolism alterations. From these results, it is clear that the mode of action of the 1,8-naphthalic anhydride is not that of a simple interference in the uptake or metabolism of EPTC but indicates that a more subtle or complicated process is involved.