Hypersensitivity pneumonitis presenting as sarcoidosis.

نویسندگان

  • L S Forst
  • J Abraham
چکیده

Pulmonary sarcoidosis and hypersensitivity pneumonitis are two disease entities that may have similar clinical, laboratory, and pathological features. A low index of suspicion for hypersensitivity pneumonitis combined with the overlapping features contribute to the difficulty of distinguishing the two diseases. Indeed, two case series suggest that four of 51 and two of 46 subjects originally diagnosed as having sarcoidosis showed clinical and histological characteristics more consistent with hypersensitivity pneumonitis.1 2 Because early recognition of hypersensitivity pneumonitis can lead to complete reversal of disease in many cases, it is important to make this diagnosis as early as possible. We present a case that was most likely misdiagnosed and resulted in continued workplace exposure, considerable morbidity, and unwarranted discharge from employment due to a probable work related illness.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

T-lymphocytosis in bronchoalveolar lavage fluid of hypersensitivity pneumonitis. Changes in profile of T-cell subsets during the course of disease.

Recently, increased proportions of OKT 4+ helper T-lymphocytes have been reported in bronchoalveolar lavage (BAL) fluid of patients with active sarcoidosis. In this study we were interested in T-cell subsets of hypersensitivity pneumonitis, a disease characterized by a similar increase in BAL T-lymphocytes as active sarcoidosis. We applied an immunoperoxidase method performed on glass slides us...

متن کامل

Pulmonary extracellular adenosine triphosphate in hypersensitivity pneumonitis and sarcoidosis – a preliminary study

................................................................................................................................... 4 Resumo ...................................................................................................................................... 5 Introduction .............................................................................................................

متن کامل

Density of phenotypic markers on BAL T-lymphocytes in hypersensitivity pneumonitis, pulmonary sarcoidosis and bronchiolitis obliterans with organizing pneumonia.

In vitro studies have shown that the density of surface antigens reflects the degree of activation of T-cells. We therefore studied the density of surface antigens on T-cells from bronchoalveolar lavage fluid (BALF) and blood in patients with sarcoidosis, hypersensitivity pneumonitis (HP) and bronchiolitis obliterans with organizing pneumonia (BOOP). BALF cells were stained with anti-CD3, anti-...

متن کامل

Chemokines in bronchoalveolar lavage fluid in summer-type hypersensitivity pneumonitis.

Hypersensitivity pneumonitis (HP) is a granulomatous interstitial lung disease caused by the inhalation of a variety of antigens and is characterized by a dramatic accumulation of inflammatory cells, including neutrophils, lymphocytes and macrophages, in the lung. The mechanisms implicated in the inflammatory cell recruitment observed in hypersensitivity pneumonitis are unknown. We examined the...

متن کامل

Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis.

Bronchoalveolar lavage fluids (BALF) from patients with idiopathic pulmonary fibrosis (IPF; n=36), hypersensitivity pneumonitis (HP; n=32) and sarcoidosis (n=44) were investigated for their surfactant properties and compared to healthy control subjects (n=29). The phospholipid (PL) and protein concentration, the PL:protein ratio, PL subclasses, and the surfactant apoproteins (SP)A and SP-B were...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • British journal of industrial medicine

دوره 50 6  شماره 

صفحات  -

تاریخ انتشار 1993