Author's response to reviews Title: Fascin overexpression promotes neoplastic progression in Oral Squamous Cell Carcinoma Authors:
نویسندگان
چکیده
Hunain Alam ([email protected]) Amruta V Bhate ([email protected]) Prakash Gangadaran ([email protected]) Sharda S Sawant ([email protected]) Shimul Salot ([email protected]) Lalit Sehgal ([email protected]) Prerana P Dange ([email protected]) Devendra A Chaukar ([email protected]) Anil K D’cruz ([email protected]) Sadhna Kannan ([email protected]) Rajiv Gude ([email protected]) Shubhada Kane ([email protected]) Sorab N Dalal ([email protected]) Milind M Vaidya ([email protected])
منابع مشابه
Fascin Expression in Oral Squamous Cell Carcinoma using an Immunohistochemical Technique
Introdouction: Oral squamous cell carcinoma (OSCC), the most common form of oral cancer, requires early diagnosis and suitable treatments. Fascin is a protein involved in cell adhesion and is increased in expression in certain types of carcinomas. The present study was conducted to assess fascin expression in OSCC using an immunohistochemical technique. Materials and methods: In the present re...
متن کاملAuthor's response to reviews Title: Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes Authors:
Title: Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes
متن کاملImmunohistochemical Evaluation of Fascin in Oral Squamous Cell Carcinoma
Background and purpose: Squamous cell carcinoma (SCC) is the eighth most common cancer in men and the fifteenth in women. Localized recurrence and metastasis to regional lymph nodes are major problems in these patients. Fascin is a 55- kDa protein from the family of actin-binding proteins that is expressed in cells with membranous bronchial tubes. The aim of this study was to evaluate the expre...
متن کاملFascin promotes migration and invasion and is a prognostic marker for oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) prognosis is related to clinical stage and histological grade. However, this stratification needs to be refined. We conducted a comparative proteome study in microdissected samples from normal oral mucosa and OSCC to identify biomarkers for malignancy. Fascin and plectin were identified as differently expressed and both are implicated in several malignancies,...
متن کاملLoss of keratins 8 and 18 leads to alterations in α6β4-integrin-mediated signalling and decreased neoplastic progression in an oral-tumour-derived cell line.
Keratins 8 and 18 (K8 and K18) are predominantly expressed in simple epithelial tissues and perform both mechanical and regulatory functions. Aberrant expression of K8 and K18 is associated with neoplastic progression and invasion in squamous cell carcinomas (SCCs). To understand the molecular basis by which K8 promotes neoplastic progression in oral SCC (OSCC), K8 expression was inhibited in A...
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