Localized Scleroderma
نویسندگان
چکیده
Morphea (localized scleroderma) is an autoimmune disease characterized by sclerosis of the skin and, in some cases, subcutaneous tissue. It occurs in children and adults. It is distinct from systemic sclerosis, but may nevertheless be associated with significant functional and cosmetic impairment. Morphea has several distinct subtypes, including circumscribed, linear, and generalized, all of which can occur in superficial and deep forms. The linear subtype is more common in children, and the circumscribed is more common in adults. Evaluation is aimed at confirming the diagnosis and clinical subtype, assessing the stage of activity, and determining the potential for/or the presence of morbidity. Therapy includes topical, phototherapy, or systemic treatments and is aimed at halting progression, preventing morbidity, and speeding remission.
منابع مشابه
Age, sex and type distribution of localized Scleroderma in patients referred to Boo-Ali Hospital in Tehran, 1995-99
Background: There is no data on the characteristics of patients with localized scleroderma in Iran. Objective: In order to determine the age, sex and type distribution of localized scleroderma in Iran, this study was done on patients referred to Boo-Ali Hospital in Tehran in 1995-1999. Patients and Methods: This study was done as an existing data study on 39 patients with localized scleroderma ...
متن کاملLocalized Scleroderma: Predisposing and Triggering Factors
The etiology of localized scleroderma remains unclear. The objective of this article is to review different theories of etiology, specifically provocative and predisposing factors for the development of localized scleroderma. The mini-review presents the factors, which may influence the occurrence of localized scleroderma. The genetic predisposition for the development of scleroderma is a relev...
متن کاملLocalized scleroderma: clinical spectrum and therapeutic update*
Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis and visceral involvement, and localized scleroderma or morphea which classically presents benign and self-limited evolution and is confined to the skin and/or underlying tiss...
متن کاملLocalized scleroderma is an autoimmune disorder.
OBJECTIVES There have been many studies suggesting that localized scleroderma has a strong autoimmune background, although the lesions are usually limited to the skin and subcutaneous tissue. Here we summarize previous data on the autoimmunity of localized scleroderma, mostly published in the last two decades, because there has not been a review paper summarizing autoimmunity in this disorder. ...
متن کاملLocalized scleroderma and hemiatrophy in association with antibodies to double-stranded DNA.
Localized scleroderma involves primarily skin but also muscle, bone and synovium. Further associations and transitional forms have been reported. We report here two cases showing associations between localized scleroderma and vasculitis, mononeuritis multiplex, juvenile chronic arthritis and hemiatrophy. In particular our cases both possess antibodies to double-stranded DNA, a finding not previ...
متن کاملEvaluation of serum concentrations of the selected cytokines in patients with localized scleroderma
INTRODUCTION Localized scleroderma is an autoimmune disease primarily affecting the skin. The cause of disease remains unexplained although environmental factors are implicated, which are likely to be responsible for activation of the endothelium and subsequent inflammation leading to excessive synthesis of collagen and extracellular matrix components. AIM To determine concentrations of inter...
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