Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin
نویسندگان
چکیده
1Dermatology & Genetic Medicine, Division of Molecular Medicine, University of Dundee, Dundee, UK 2Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK 3Laboratory of Gene Medicine, Keio University School of Medicine, Tokyo, Japan 4Center for Integrated Medical Research, Keio University School of Medicine, Tokyo, Japan 5Department of Dermatology, Keio University School of Medicine, Tokyo, Japan 6Department of Paediatric Dermatology, Our Lady’s Children’s Hospital, Dublin, Ireland 7Department of Clinical Medicine, Trinity College, Dublin, Ireland 8Division of Dermatology, Department of Medicine, University of Capetown, South Africa 9Alan Lyell Centre for Dermatology, Southern General Hospital, Glasgow, UK 10Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, Japan
منابع مشابه
SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing
The stratum corneum (SC), the outermost layer of the epidermis, acts as a barrier against the external environment. It is hydrated by endogenous humectants to avoid desiccation. However, the molecular mechanisms of SC hydration remain unclear. We report that skin-specific retroviral-like aspartic protease (SASPase) deficiency in hairless mice resulted in dry skin and a thicker and less hydrated...
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