Aipha - Antitrypsin Pi - Types in 965 COPD Patients
نویسنده
چکیده
To study further the role of intermediate alpha1-antitrypsin (AAT) deficiency in chronic obstructive pulmonary disease (COPD), AAT Pi-types and serum.trypsin-inhibitory-capacity (STIC) were measured in 965 patients th CQPD. Heterozygosity of the Z variant was the major cause of intermediate AAT deficiency (primarily the MZ phenotype), accounting for 8.0 percent of the patients compared to 2.9 percent ofcontrol subjects (p<.0005) ZZ homozygosity was detected in 1.9 percent of the patients, compared to 0.04 percent of control studies performed by others (none was present in our own control group of 1,380 subjects). The
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