Recombination in the Absence of Ig - Maturation but Have Intact VDJ B Cell
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The Serine/Threonine Phosphatase PP4 Is Required for Pro-B Cell Development through Its Promotion of Immunoglobulin VDJ Recombination
PP4 phosphatase regulates a number of crucial processes but the role of PP4 in B cells has never been reported. We generated B cell-specific pp4 knockout mice and have identified an essential role for PP4 in B cell development. Deficiency of PP4 in B lineage cells leads to a strong reduction in pre-B cell numbers, an absence in immature B cells, and a complete loss of mature B cells. In PP4-def...
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ment, producing two coding ends and two signal ends. Howard Hughes Medical Institute Subsequent joiningof thecoding ends, forming a coding Baylor College of Medicine joint, assembles a rearranged TCR or Ig gene segment; Houston, Texas 77030 the signal ends also join, forming a signal joint. †Department of Molecular Biology and Genetics Several features of VDJ recombination are reminisHoward Hug...
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