Leukemia Inhibitory Factor and Human Endometrial Receptivity
نویسندگان
چکیده
Embryo implantation requires both an activated blastocyst and a receptive endometrium. The human endometrium undergoes extensive remodeling in each menstrual cycle to prepare the endometrium for implantation, should conception occur in that cycle. For most of the cycle, the endometrium is retained in a non-receptive or refractory state and it will support implantation of the blastocyst for only about 4 days commencing around 6 days after the luteinizing hormone (LH) peak (during the mid secretory phase) of a normal menstrual cycle, a time known as the ‘window of implantation’ (1). The preparation for pregnancy includes differentiation of the glands into a highly secretory state and changes in cell surface proteins and adhesion molecules on the apical and basolateral surfaces of the luminal epithelium. In the stromal compartment, changes are initiated in the fibroblasts close to the spiral arterioles, that lead to differentiation (decidualization) of these cells into decidual cells – this process continues as pregnancy is established to form the decidua of pregnancy.
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